From: Drug-drug relationship based on target information: application to drug target identification
Drug Name | Known Targets | Score (frequency for score ties) from the positive drug-pairs | Rank | Score (frequency for score ties) from the newly predicted drug-pairs (not sharing a target) | Rank |
---|---|---|---|---|---|
DMT (DB01488) | 5-HT7 5-HT1B 5-HT5A 5-HT6 5-HT1D 5-HT1A σ1 5-HT2A 5-HT2C 5-HT2B | 0.858(10) 0.858(14) NA 0.858(6) 0.858(16) 0.910 0.772 0.942(63) 0.942(32) 0.882 | 40 39 NA 42 38 17 52 1 3 32 | 0.426 0.778(4) NA NA 0.778(4) 0.529(2) NA NA 0.376 0.778(2) | 75 3 NA NA 3 45 NA NA 99 5 |
K+ | 0.939 [Potassium H2] | 16 | 0.655 [Potassium D2,D3,KQT2,A1] | 28 | |
hERG | NA | NA | NA | NA | |
D2 | 0.961(63) | 1 | NA | NA | |
Motilium (DB01184) | D3 | 0.917 | 22 | NA | NA |
α1 | α1A 0.961(26) | 4 | α1B 0.700(1) | 18 | |
α1B 0.961(20) | 7 | α1A 0.694 | 20 | ||
5(HT2A) | 0.961(41) | 2 | 0.752 | 10 | |
VMAT2 | 0.878 | 1 | NA | NA | |
Xenazine (DB04844) | α2 | α2A 0.807 | 14 | α2A 0.706 | 4 |
α2B 0.758 | 15 | α2B 0.650 | 37 | ||
Prantal (DB00729) | δ M3 | 0.975 0.986 | 21 1 | 0.830 NA | 49 NA |
M1 | 0.954(71) | 1 | NA | NA | |
M2 | 0.954(58) | 2 | NA | NA | |
M3 | 0.954(53) | 3 | NA | NA | |
β1- | 0.918 [β1 adrenergic receptor] | 31 | 0.635 [β1 adrenergic receptor] | 24 | |
Paxil (DB00715) | DAT | 0.951(24) | 10 | 0.775 | 4 |
NET | 0.951(45) | 6 | NA | NA | |
5-HTT | 0.951(42) | 7 | NA | NA | |
α1 | α1A 0.951(41) | 8 | α1A 0.687 | 15 | |
α1B 0.939 | 12 | α1B 0.545 | 60 | ||
Prozac (DB00472) | 5HTT NET β1- CA H1 5-HT2C 5-HT2A M1 | 0.992(42) 0.992(32) 0.988 [β1 adrenergic receptor] NA 0.992(25) 0.991(35) 0.992(63) 0.992(23) | 2 4 18 NA 5 14 1 6 | NA 0.861 0.699 [β1 adrenergic receptor] CA2, 0.280 0.776 NA NA 0.735(8) | NA 3 106 357 86 NA NA 89 |
Rescriptor (DB00705) | H4 HIVRT *Gag-Pol | NA NA 0.847 | NA NA 1 | 0.259 NA NA | 47 NA NA |
PTGS2 | 0.923 | 1 | NA | NA | |
PDPK1 | 0.746 | 21 | NA | NA | |
CA2 | NA | NA | 0.824 | 1 | |
Kv | 0.505 [Kv subfamily C member 4] | 177 | 0.451 [Kv subfamily KQT member 1] | 47 | |
0.451 [Kv subfamily E member 1] | 48 |