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Figure 3 | BMC Systems Biology

Figure 3

From: A trigger model of apoptosis induced by tumor necrosis factor signaling

Figure 3

Model simulation results for caspase activities Model simulation results for pro-caspase-8 (A), pro-caspase-3 (B), caspase-8 (C) and caspase-3(D). In (A) and (B), the experimental data (circle dots) are retrieved from [12], Fig. 3, which include time courses for pro-caspase-8 and -3 in Jurkat cells in the presence of 100ng/ml FasL at room temperature. In the simulation, [TNF] was set to 2.0nM to mimic the stimuli associated with 100ng/ml FasL [12]. The total concentration of FasL receptor was also set to [TNF-R]0 = 10.0nM according to [12].

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