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Table 7 Observed extracellular rates for several metabolic phases within three fed-batch cultures

From: Cell functional enviromics: Unravelling the function of environmental factors

 

Fed-batch 1

Fed-batch 2

Fed-batch 3

Robs

Ph I

Ph II

Ph III

Ph IV

Ph I

Ph II

Ph III

Ph IV

Ph V

Ph I

Ph II

Ph III

Ph IV

Ph V

 

(21-45 h)

(45-70 h)

(70-95 h)

(95-118 h)

(25-50 h)

(50-70 h)

(70-90 h)

(90-110 h)

(110-135 h)

(50-75 h)

(75-100 h)

(100-125 h)

(125-150 h)

(150-175 h)

μ

0.019

0.022

0.022

0.012

0.020

0.020

0.018

0.014

0.009

0.020

0.017

0.014

0.009

0.008

rGlc

-190.33

-76.60

-71.99

-50.89

-187.25

-88.71

-74.53

-78.89

-51.89

-99.03

-71.38

-99.38

-63.53

-75.45

rGln

-8.74

-3.56

-5.24

-4.31

-10.23

-7.39

-2.02

-1.85

-1.20

-12.46

-3.73

-2.85

-1.47

-1.62

rLac

324.81

68.80

19.97

8.95

206.02

116.56

76.71

59.78

46.56

94.97

32.10

59.04

24.52

17.45

rAmm

9.85

12.94

10.50

9.68

16.32

12.75

9.88

8.17

6.34

9.83

9.40

12.91

14.04

12.47

rIgG

0.000215

0.000326

0.000291

0.000224

0.000167

0.000257

0.000301

0.000308

0.000264

0.000214

0.000280

0.000317

0.000368

0.000465

rGlu

3.90

-8.26

-15.43

-14.25

5.86

-9.97

-14.42

-18.72

-13.34

-3.49

-9.18

-12.19

-10.96

-13.61

rAla

0.13

-2.63

-2.83

-1.91

0.45

-2.34

-3.00

-2.27

-1.54

-1.65

-4.23

-4.16

-1.93

-0.56

rAsp

-15.89

-14.38

-8.20

-0.54

-12.71

-9.51

-2.22

-0.50

0.01

-5.96

-4.52

-4.34

-2.93

-2.33

rSer

-19.18

-16.59

-14.63

-3.06

-13.63

-10.89

-13.84

-14.43

-7.80

-15.58

-11.79

-10.03

-5.69

-4.47

rAsn

2.91

-3.98

-3.24

-2.31

-3.30

-3.05

-2.55

-1.86

-1.45

0.30

-2.37

-3.96

-2.96

-2.70

rGly

13.83

7.17

1.26

-0.01

9.50

7.34

6.18

5.84

5.16

8.53

6.30

3.66

1.93

0.47

rHis

-3.17

-2.80

-1.67

0.87

-1.08

-1.10

-0.65

-0.67

-0.47

-2.53

-0.78

-0.73

-0.52

-0.56

rThr

-3.30

-3.65

-3.47

-1.79

-2.99

-2.95

-2.53

-1.74

-1.30

-2.58

-2.10

-2.47

-1.37

-1.33

rArg

-3.15

-2.88

-3.38

-1.93

-2.88

-2.88

-2.55

-2.52

-1.41

-2.69

-2.35

-2.27

-1.47

-1.26

rPro

-5.84

-5.27

-1.81

-1.00

-5.82

-2.93

-0.83

0.90

1.60

9.34

2.41

-1.07

-0.39

-0.09

rTyr

-1.75

-1.35

-1.56

-1.13

-1.97

-1.41

-0.58

-0.39

-0.21

-1.17

-1.13

-1.02

-0.75

-1.08

rCys

-2.97

-2.58

-1.59

-0.88

-3.03

-1.45

-2.98

-3.34

-1.84

-3.36

-2.63

-2.54

-1.69

-1.41

rVal

-3.51

-3.84

-3.68

-2.04

-2.96

-2.82

-2.53

-2.20

-1.40

-2.56

-2.03

-2.50

-1.95

-1.77

rMet

-3.06

-4.76

-2.46

-0.72

-2.35

-1.89

-1.35

-0.82

-0.50

-1.68

-1.06

-1.46

-1.21

-1.32

rIle

-2.52

-3.16

-2.59

-1.54

-2.89

-2.40

-1.99

-1.41

-1.12

-1.93

-1.59

-1.68

-1.68

-1.47

rLeu

-4.66

-5.52

-5.11

-2.67

-5.01

-4.51

-3.47

-2.90

-1.85

-3.83

-3.07

-4.68

-3.29

-2.74

rLys

-5.62

-4.46

-4.27

-2.32

-5.25

-4.08

-3.35

-2.59

-2.07

-3.31

-3.62

-4.77

-2.96

-1.65

rPhe

-2.69

-2.27

-1.83

-0.75

-1.70

-1.60

-1.94

-3.25

-1.03

-0.98

-0.93

-0.98

-0.79

-0.80

  1. Units are in nmol.(106cells.h)-1. A minus sign indicates consumption. μ refers to the specific growth rate (h-1), calculated using the concentrations of viable cells