Figure 11

Test set prediction results from HC-PLSR, PLSR and OLS for the mouse ventricular myocyte. Histograms of A) R² values and B) RMSEP values from test set predictions of the mouse ventricular myocyte state variable time series as functions of the parameters, with HC-PLSR, global polynomial PLSR and global polynomial OLS. The average values over the three data set parts (separated according to the stimulus period) are shown. In HC-PLSR, 2-20 PLS components were used in the regression models, while in PLSR 2-8 PLS components were used. The mean R²_{test set} over all state variables was 0.98 for HC-PLSR and 0.94 for both PLSR and OLS.