| SGA | GIM | E-MAP |
---|
SGA
| 810 | 4723 | 82 | 645 | 3217 | 16481 |
GIM
| 0.14% | 1.11% | 0 | 85 | 141 | 603 |
E-MAP
| 1.75% | 8.95% | 1.13% | 4.84% | 1607 | 5297 |
- The values above and below the diagonal give the number and percentage, respectively, of known genetic interactions in each of the pairwise intersections as available from BioGRID (version 3.0.64). Left, positive interactions; Right, negative interactions. Only the unambiguous mutant pairs were used here in the comparative evaluations. The BioGRID interactions extracted from these three datasets under the study were pairwise excluded from the positive and negative classes of reference interactions. The diagonal gives the number of interactions excluded from each of the individual datasets. In addition to the E-MAP dataset used in the present analyses, the BioGRID database contains genetic interactions extracted from three other large-scale screening studies performed with the E-MAP approach [4, 6, 7]. The three dataset intersections contained such interactions as follows (negative/positive interactions): SGA - GIM 37 (45%)/52 (8%), SGA - E-MAP 755 (23%)/1458 (9%), and GIM - E-MAP: 36 (26%)/46 (8%).