Figure 2
From: Understanding dynamics using sensitivity analysis: caveat and solution
Local parametric sensitivity analysis of x 6 activation under x 1 stimulus. The bar graphs show the consolidated sensitivity metrics of x 6 with respect to model parameters based on (a) infinite norm, (b) Fisher Information Matrix (FIM) and (c) time integrated sensitivity coefficients; and (d) the sensitivity magnitudes at switching time (t = 7.12 time units). The parameter numbers refer to the reactions as shown in Figure 1, where the subscripts f denotes the forward rate constant and k and v denotes the rate constants of Michealis-Menten kinetics.