Figure 4

MC for four independent E. coli metabolic network reconstructions. (A) The network obtained from the EcoCyc database pathway information. (B) The network obtained from the KEGG pathways. (C) The network subset of the i AF1260 network where currency metabolites have been removed manually. (D) The i AF1260 network (currency metabolites have been removed manually) consisting only of reactions active under a rich medium condition. Error bars represent the standard deviation of a jackknife test, where the MC was recomputed 100 times by discarding 10% of the transcript data for each of the four genetic backgrounds.