Figure 1

Sensitivity analysis of viral production and biomass production fluxes. Sensitivity analysis of biomass or product synthesis estimations was performed when the measured value of each of these fluxes was individually omitted from the complete model, yielding an overdetermined system of equations (see text and Methods section). The estimation of fractional sensitivities was achieved by factoring the appropriate average value of measured metabolite consumption/production rates and average value of measured cell growth rate or productivity, respectively, from all available culture conditions (see Table 2). Horizontal axis marks indicate computed sensitivities are zero.