Figure 4

Cell Population Sensitivity Analysis. (A) - (F) Time of death for 2500 cells with lognormally distributed production rates, plotted as a projection versus one of these rates normalized by its nominal value. Cells not dying within 100 hours post stimulus with TNF are classified as survivors and plotted as magenta or cyan dot in the zone "> 100" at a random ordinate, the others are plotted as red or blue dot. The number of dying cells is approximated using robust linear regression (black solid lines) and an estimate of the standard deviation of the error (black dash-dotted lines). (A), (C), (E) continuous stimulation with 10 ng/ml TNF. (B), (D), (F) 30 minute pulse stimulation with 10 ng/ml TNF. (A) - (B) projection with respect to the production rate of TNF receptors, (C) - (D) to IκBα mRNA expression and (E) - (F) to XIAP production.