Figure 3

Simulations of the Single Cell Model. (A) and (B) Single cell time course simulations of relative NF-κB translocation into the nucleus and Caspase-3 activation for TNF concentrations in the range of 0.01 - 100 ng/ml; (A) for continuous TNF stimulation and (B) for 30 minute TNF pulse stimulation. Relative activities represent the concentration time courses divided by their maximum values. For NF-κB, the relative activity is color coded such that blue depicts a low, yellow a medium and red a high nuclear accumulation. For Caspase-3, the color of a complete trajectory stands for the time of death: early death in red, late death in yellow, cell survival in green.