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Figure 5 | BMC Systems Biology

Figure 5

From: DnaA and the timing of chromosome replication in Es-cherichia coli as a function of growth rate

Figure 5

Predictions of the model can distinguish between different scenarios. Two possible scenarios can result in a constant initiation threshold for the model. In the first the binding affinity of DnaA-ATP to its repressor sites decreases with increasing cell doubling time, and in the second the RIDA rate increases with cell doubling time. In both scenarios k A (the basal transcription rate) must decrease with increasing cell doubling time.

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