Table 2 Sensitivity of feedback loop to changes in stochasticity parameters
From: The role of noise and positive feedback in the onset of autosomal dominant diseases
Trial | Expression level | Noise stdev | Time scale (days) | Penetrance | Mean onset |
|---|---|---|---|---|---|
1b | 50% | 0.2 | 2 | 0.31 | 2.1/5.9 |
2 | 50% | 0.5 | 2 | 0.94 | 22.1/20.4 |
3 | 50% | 1.0 | 2 | 1.0 | 12.5/10.6 |
4 | 50% | 0.2 | 5 | 0.91 | 21.9/21.8 |
5c | 52.5% | 0.5 | 2 | 0.20 | 6.1/18.7 |
6 | 52.5% | 1.0 | 2 | 0.95 | 17.8/15.9 |
7d | 52.5% | 0.5 | 5 | 0.54 | 7.5/13.0 |
8 | 52.5% | 1.0 | 5 | 1.0 | 22.0/18.5 |
9 | 55% | 0.5 | 2 | 0.0 | -- |
10 | 55% | 0.5 | 5 | 0.0 | -- |
11e | 55% | 1.0 | 2 | 0.34 | 8.8/19.2 |
12 | 55% | 1.0 | 5 | 1.0 | 2.7/0.1 |
13f | 60% | 1.0 | 5 | 0.0 | -- |