From: microRNA evolution in a human transcription factor and microRNA regulatory network
Analysis | Results |
---|---|
Coevolution of TF-miRNA | R = 0.19, P = 0.003, Spearman's correlation |
Coevolution of TF-activating-miRNA | R = 0.20, P = 0.01, Spearman's correlation |
Coevolution of TF-repressing-miRNA | R = -0.04, P = 0.77, Spearman's correlation |
Coevolution of TF-activating-gene | R = 0.08, P = 0.05, Spearman's correlation |
Coevolution of TF-repressing-gene | R = -0.06, P = 0.27, Spearman's correlation |
Evolutionary rates of targets regulated by rapidly evolving and slowly evolving miRNAs, respectively | Median dN 0.047 vs. 0.051, P = 0.05, Wilcoxon test |