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Table 1 Functional analysis of genes differentially expressed in ovaries during 24 hr fadrozole exposure

From: Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk

ENRICHED GO TERMS UP-REGULATED FOR FAD IN VITRO

ENRICHED GO TERMS UP-REGULATED FOR FAD IN VIVO

GO Name

p Value

GO Name

p Value

morphogenesis of an epithelium

0.011

pregnancy

0.009

protein amino acid glycosylation

0.029

ossification

0.012

glycoprotein biosynthesis

0.033

regulation of cell growth

0.012

biopolymer glycosylation

0.034

amino acid derivative catabolism

0.020

embryonic development (sensu Metazoa)

0.046

tissue development

0.021

glycoprotein metabolism

0.046

anti-apoptosis

0.027

  

cell differentiation

0.029

  

osteoblast differentiation

0.031

  

development

0.036

  

oogenesis

0.042

  

reproductive physiological process

0.043

  

nucleoside triphosphate metabolism

0.044

ENRICHED GO TERMS DOWN-REGULATED FOR FAD IN VITRO

ENRICHED GO TERMS DOWN-REGULATED FOR FAD IN VIVO

GO Name

p Value

GO Name

p Value

gastrulation

0.008

negative regulation of apoptosis

0.002

DNA replication

0.009

anti-apoptosis

0.003

cellular carbohydrate metabolism

0.016

negative regulation of programmed cell death

0.003

carbohydrate metabolism

0.019

purine ribonucleotide biosynthesis

0.004

potassium ion transport

0.021

pregnancy

0.006

macromolecule biosynthesis

0.023

nucleoside triphosphate metabolism

0.007

glucose catabolism

0.025

transcription from RNA polymerase II promoter

0.009

hexose catabolism

0.026

regulation of physiological process

0.012

monosaccharide catabolism

0.026

signal transduction

0.013

positive regulation of cellular process

0.026

purine nucleoside triphosphate biosynthesis

0.015

alcohol catabolism

0.027

nucleoside triphosphate biosynthesis

0.016

physiological process

0.028

G-protein signaling, coupled to cyclic nucleotide second messenger

0.020

energy derivation by oxidation of organic compounds

0.032

reproductive organismal physiological process

0.021

mitochondrial transport

0.033

nucleoside metabolism

0.024

positive regulation of biological process

0.035

reproductive physiological process

0.024

glucose metabolism

0.036

energy coupled proton transport, down electrochemical gradient

0.024

protein amino acid glycosylation

0.040

ATP synthesis coupled proton transport

0.024

muscle contraction

0.042

regulation of cellular physiological process

0.026

protein biosynthesis

0.043

cell-cell adhesion

0.027

glycoprotein biosynthesis

0.044

cell proliferation

0.031

carbohydrate catabolism

0.044

regulation of programmed cell death

0.038

cellular carbohydrate catabolism

0.044

apoptosis

0.038

biopolymer glycosylation

0.045

G-protein signaling, coupled to cAMP nucleotide second messenger

0.038

cellular process

0.046

development

0.040

  1. **The full list of significant GO terms are in Additional File 1.