Table 1 Optimal model parameters
From: Robustness from flexibility in the fungal circadian clock
Parameter, k j | Description | Value |
|---|---|---|
a1 (h-1) | Max. rate: WC-1* upregulated frq transcription | 8.3450 |
a2 (h-1) | Max. rate: WC-1 upregulated frq transcription | 3.7925 |
a3 (h-1) | FRQ translation rate | 0.3154 |
a4 (h-1) | Basal wc-1 transcription rate | 0.6787 |
a5 (h-1) | Max. rate: WC-1* upregulated wc-1 transcription | 10.0718 |
a6 (h-1) | Basal WC-1 translation rate | 6.6644 |
a7 (nM-1h-1) | FRQ upregulated WC-1 translation rate | 2.4695 |
b1 (nM-1) | Michaelis constant: repression of WC-1* upregulated frq transcription | 4.1472 |
b2 (nM) | Michaelis constant: WC-1* upregulated frq transcription | 0.1560 |
b3 (nM-1) | Michaelis constant: repression of WC-1 upregulated frq transcription | 0.7149 |
b4 (nM) | Michaelis constant: WC-1 upregulated frq transcription | 2.9415 |
b5 (nM) | Michaelis constant: frq mRNA degradation | 4.1075 |
b6 (nM) | Michaelis constant: degradation of active FRQ | 0.4715 |
b7 (nM) | Michaelis constant: WC-1* upregulated wc-1 transcription | 3.5676 |
b8 (nM) | Michaelis constant: wc-1 mRNA degradation | 0.5805 |
b9 (nM) | Michaelis constant: degradation of active WC-1 | 7.0233 |
b10 (nM) | Michaelis constant: degradation of WC-1* | 0.8218 |
d1 (h-1) | Max. rate: frq mRNA degradation | 7.4608 |
d2 (h-1) | Max. rate: degradation of active FRQ | 0.4405 |
d3 (h-1) | Max. rate: wc-1 mRNA degradation | 2.1710 |
d4 (h-1) | Max. rate: degradation of active WC-1 | 3.0883 |
d5 (h-1) | Max. rate: degradation of WC-1* | 23.3120 |
f 1 (h-1) | Delay parameter: FRQ → active FRQ conversion | 0.1962 |
f 2 (h-1) | Delay parameter: WC-1 → active WC-1 conversion | 0.1317 |
γ1 (h-1) | Loss rate: FRQ → active FRQ conversion (deg. rate of intermediates) | 0.0422 |
γ2 (h-1) | Loss rate: WC-1 → active WC-1 conversion (deg. rate of intermediates) | 0.0244 |
r1 (h-1) | Rate of active WC-1 → WC-1* conversion | 5.1759 |
r2 (h-1) | Rate of WC-1* → active WC-1 conversion | 5.0326 |
n | Hill coefficient: WC-1* upregulated frq transcription | 1.0168 |
m | Hill coefficient: WC-1 upregulated frq transcription | 2.8134 |
k | Hill coefficient: WC-1* upregulated wc-1 mRNA transcription | 1.4135 |
g | Hill coefficient: repression of WC-1* upregulated frq transcription | 1.2730 |
h | Hill coefficient: repression of WC-1 upregulated frq transcription | 3.6978 |