Table 1 Annotation of genes identified in EDNRB network.
Symbol | Comments | Motifs | Z-score |
|---|---|---|---|
EDNRB | Endothelin receptor type B. Mutation causes Hirschsprung disease type 2 (HSCR2) [MIM:600155] | 7tm_1 | -1.1 |
GNA11 | G-protein activates phospholipase C in endothelin pathway | Gα | -1.9 |
EDN3 | Ligand for endothelin receptor type B | EDN | 0.2 |
PLCD1 | Phospholipase produces diacylglycerol and inositol 1,4,5-trisphosphate in endothelin pathway | PH-PLC, C2_2, EFh | -1.5 |
TAOK1 | Kinase activates the p38 MAP kinase pathway in endothelin pathway | SbcC, STKc_TAO | -0.2 |
PTK2B | Kinase regulates ion channel and activation of the MAP kinase signaling pathway in endothelin pathway | PTKc_FAK, FERM_M. Focal_AT, B41, Pkinase_Tyr | -1.9 |
AGTR1 | Receptor for angiotensin II; defect causes renal tubular dysgenesis (RTD) [MIM:267430] | 7tm_1 | -1.7 |
RING1 | E3 ubiquitin-protein ligase for histone H2A | RING-finger | 0.5 |
FHOD1 | Required for the assembly of F-actin structures | FH, GBD | 0.2 |
DPYSL2 | Signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton | D-HYD | -0.5 |