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Table 2 Data for the frustration index δ.

From: Monotonicity, frustration, and ordered response: an analysis of the energy landscape of perturbed large-scale biological networks

Network δ low δ up δ max δ null σ null Z score Pvalue
transcriptional        
E. Coli 365 371 1579 662,86 9,77 29,86 p 10-100
Yeast 41 41 401 116,67 5,83 12,98 p = 8 · 10-39
B. Subtilis 71 71 415 139,73 6,53 10,52 p = 3,5 · 10-26
Cory 9 9 48 71,15 2,16 3,76 p = 8,3 · 10-5
signaling        
EGFR 183 193 375 149,75 5,01 -8,62 p = 3,3 · 10-18
Toll-like 401 468 873 384,92 7,70 -10,78 p = 2,1 · 10-27
metabolic        
Yeast metab 670 747 1421 667,42 10,3 -7,72 p = 5,6 · 10-15
Ecoli metab 912 1017 1944 1006,9 12,73 -0,79 p = 0,21
  1. δlow and δup are the computational lower and upper bounds found for δ by the algorithms described in Supplementary Notes in Additional File 1; δmax is the theoretical upper bound. The Z-score statistics for the frustration index δ is based on the null model obtained reshuffling the signs (see Supplementary Notes in Additional File 1). δnull and δnull are mean and standard deviation of the null model. The Z-score compares this statistics with the "true" δ (here we use δup, more conservative).