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Table 2 Data for the frustration index δ.

From: Monotonicity, frustration, and ordered response: an analysis of the energy landscape of perturbed large-scale biological networks

Network

δ low

δ up

δ max

δ null

σ null

Z score

Pvalue

transcriptional

       

E. Coli

365

371

1579

662,86

9,77

29,86

p≪ 10-100

Yeast

41

41

401

116,67

5,83

12,98

p = 8 · 10-39

B. Subtilis

71

71

415

139,73

6,53

10,52

p = 3,5 · 10-26

Cory

9

9

48

71,15

2,16

3,76

p = 8,3 · 10-5

signaling

       

EGFR

183

193

375

149,75

5,01

-8,62

p = 3,3 · 10-18

Toll-like

401

468

873

384,92

7,70

-10,78

p = 2,1 · 10-27

metabolic

       

Yeast metab

670

747

1421

667,42

10,3

-7,72

p = 5,6 · 10-15

Ecoli metab

912

1017

1944

1006,9

12,73

-0,79

p = 0,21

  1. δlow and δup are the computational lower and upper bounds found for δ by the algorithms described in Supplementary Notes in Additional File 1; δmax is the theoretical upper bound. The Z-score statistics for the frustration index δ is based on the null model obtained reshuffling the signs (see Supplementary Notes in Additional File 1). δnull and δnull are mean and standard deviation of the null model. The Z-score compares this statistics with the "true" δ (here we use δup, more conservative).