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Figure 4 | BMC Systems Biology

Figure 4

From: The biological context of HIV-1 host interactions reveals subtle insights into a system hijack

Figure 4

Essentiality and topological properties of the human network. (A) Relationship between protein degree and essentiality. Protein degree and the percentage of essential genes (blue) demonstrate a positive linear relationship (p-value of 2.52 × 10-6, r2 = 0.92). Excluding overlapping disease-associated genes from the essential set (purple) does not alter the relationship (p-value of 9.87 × 10-6 r2 = 0.89). (B) Relationship between protein betweenness centrality and essentiality. As for panel A, but for betweenness centrality. The percentage of essential genes (blue) demonstrate a positive linear relationship with betweenness (p-value of 5.86 × 10-5, r2 = 0.90). Similarly excluding overlapping disease-associated genes from the essential set (orange) does not alter the relationship, (p-value of 6.14 × 10-5, r2 = 0.88). (C) Relationship between publication count and essentiality. Essential genes (green) have an average greater publication count than non-essential genes (grey): 64 to 14 publications, respectively.

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