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Table 1 Model invalidation results for the Michaelis-Menten mechanism

From: Set-base dynamical parameter estimation and model invalidation for biochemical reaction networks

Initial Conditions

Maximum Error

substrate ( s0)

complex ( c0)

σ [%]

0.999

0.001

±14.0%

0.990

0.010

±13.0%

0.900

0.100

±8.5%

0.800

0.100

±8.0%

0.800

0.200

±5.0%

0.700

0.300

±2.5%

0.600

0.400

±0.5%

  1. Results of the model invalidation of the Michaelis-Menten mechanism. For each choice of initial conditions (concentration of substrate and complex), we report the largest error σ (in percentage) for which the resulting uncertain measurements allow to invalidate the Michaelis-Menten model.