Figure 2

A global protein-protein interaction network of four key protein kinases was reconstructed and annotated. The protein-protein interaction map includes four key protein kinases and their neighbouring proteins. (a) The four key protein kinases interact with other proteins: Ash color: direct interaction, Deep Ash color: diagonal interaction and Red color: more than two proteins interact with the same protein. (b) Positions 1, 2, 3, and 4 show the neighbors of the four key proteins; Positions 5, 6, 7, and 8 show the proteins having interactions with any two of the four key proteins; Positions 9, 10, 11 and 12 show the proteins having interactions with any three of the four key proteins; and Position 13 shows the proteins having interactions with all the four key proteins.