Table 2 Top-20 high-traffic proteins in the HF core network.
Protein | Network module | BP | CC | Traffic |
|---|---|---|---|---|
FN1 | 7 | cell adhesion, response to wounding | extracellular region | 140037.9 |
PDGFRB | 16 | positive regulation of cell proliferation, positive regulation of cell migration | ? | 118789.9 |
ITGB1 | 13 | homophilic cell adhesion, leukocyte adhesion | cell surface | 107208.2 |
C3 | 1 | G-protein coupled receptor protein signaling pathway | extracellular region | 53979.1 |
COL1A1 | 7 | blood vessel development | plasma membrane | 48837.3 |
TGFB1 | 6 | connective tissue replacement during inflammatory response | extracellular region | 45861.8 |
MMP2 | 9 | proteolysis | extracellular space | 43355.8 |
PTEN | 17 | regulation of cyclin-dependent protein kinase activity | cytoplasm | 43018.0 |
CHGB | 17 | ? | ? | 42398.0 |
ITGB3 | 7 | blood coagulation | integrin complex | 41256.5 |
ADAM15 | 16 | cell-matrix adhesion | ? | 36080.8 |
IL6ST | 16 | positive regulation of cardiac muscle hypertrophy | interleukin-6 receptor complex | 35295.1 |
COL2A1 | 7 | collagen fibril organization | collagen type II | 33618.7 |
TNFSF11 | 9 | immune response | extracellular region | 32703.6 |
ITGAV | 9 | cell adhesion | cytoplasm | 31291.3 |
PDGFRA | 16 | cell activation | integral to plasma membrane | 31130.0 |
LRP1 | 9 | lipid metabolic process | membrane fraction | 30483.8 |
SRC | 16 | protein kinase cascade | plasma membrane | 28672.6 |
MMP9 | 9 | macrophage differentiation | extracellular space | 27463.8 |
TNF | 12 | anti-apoptosis | plasma membrane | 27462.7 |