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Table 2 GO term classifications correlated with PC1 of a PLS-DA analysis. assessed by GO term classification counts of the 20 Gene Ontology Biological process terms most strongly correlated with PC 1 within a PLS-DA analysis that separates control worms from worms exposed to an approximate EC50 for each of the three tested chemicals.

From: Linking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans

GO Class ID

Definitions

Cd

FA

AZ

GO:0008150

biological process

20

20

20

GO:0008152

metabolism

5

8

15

GO:0016043

cell organization and biogenesis

4

5

6

GO:0009056

catabolism

1

7

3

GO:0006810

transport

4

4

2

GO:0000003

reproduction

2

2

 

GO:0006139

nucleic acid metabolism

3

 

8

GO:0006996

organelle organization and biogenesis

4

 

6

GO:0006259

DNA metabolism

1

 

5

GO:0015031

protein transport

 

3

1

GO:0007010

cytoskeleton organization and biogenesis

3

  

GO:0006629

lipid metabolism

1

  

GO:0007049

cell cycle

5

  

GO:0005975

carbohydrate metabolism

 

2

 

GO:0009058

biosynthesis

  

2

GO:0019538

protein metabolism

  

2

GO:0006519

amino acid and derivative metabolism

  

6

GO:0006412

protein biosynthesis

  

2