The internal state of medium spiny neurons varies in response to different input signals

BMC Systems Biology

Table 1 Mapping capability of the DARPP-32 system between neuronal signals and phosphorylation profiles of PKA and PP1

Input Signal		DARPP-32 Status		Output
Dopamine^a	Glutamate^a	Thr₃₄^b	Thr₇₅^b75	PKA^b	PP1^b
Any signal of millisecond to second scale		Δ≡	∇≡	Δ≡	∇≡
	ms-sp-tt-ha	∇↓	∇↓	∇↓	Δ↑
	ms-sp-tt-la	∇≡	∇≡	Δ≡	Δ≡
	ms-sp-st-ha	∇≡	∇≡	Δ≡	Δ≡
	ms-sp-st-la	∇≡	∇≡	↔≡	Δ≡
	ms-rp-tt-ha	∇↓	∇↓	∇↓	Δ↑
	ms-rp-tt-la	∇≡	∇≡	Δ≡	Δ≡
	ms-rp-st-ha/la	∇≡	∇≡	Δ≡	Δ≡
	s-sp-tt-ha	∇≡	∇≡	Δ≡	Δ≡
	s-sp-tt-la	∇≡	∇≡	↔≡	↔≡
	s-sp-st-ha	∇≡	∇≡	Δ≡	Δ≡
	s-sp-st-la	∇≡	↔≡	↔≡	Δ≡
	s-rp-tt-ha/la	∇≡	∇≡	Δ≡	Δ≡
	s-rp-st-ha	∇≡	∇≡	Δ≡	Δ≡
	s-rp-st-la	∇≡	Δ≡	↔≡	Δ≡
ms-sp-tt-ha	ms-sp-tt-ha	∇↓	∇↓	∇↓	Δ↑
ms-sp-tt-la	ms-sp-tt-la	∇≡	∇≡	Δ≡	Δ≡
ms-sp-st-ha/la	ms-sp-st-ha/la	∇≡	∇≡	Δ≡	Δ≡
ms-rp-tt-ha	ms-rp-tt-ha	∇↓	∇↓	∇↓	Δ↑
ms-rp-tt-la	ms-rp-tt-la	∇≡	∇≡	Δ≡	Δ≡
ms-rp-st-ha/la	ms-rp-st-ha/la	∇≡	∇≡	Δ≡	Δ≡
s-sp-tt-ha	s-sp-tt-ha	∇≡	∇≡	Δ≡	Δ≡
s-sp-tt-la	s-sp-tt-la	Δ≡	∇≡	Δ≡	∇≡
s-sp-st-ha/la	s-sp-st-ha/la	Δ≡	∇≡	Δ≡	∇≡
s-rp-tt-ha/la	s-rp-tt-ha/la	∇≡	∇≡	Δ≡	Δ≡
s-rp-st-ha/la	s-rp-st-ha/la	∇≡	∇≡	Δ≡	Δ≡

^a: Abbreviations for neurotransmission patterns are: millisecond (ms), second (s), a single pulse (sp), repetitive pulses (rp), transient transmission (tt), sustained transmission (st), high amplitude signal (ha), and low amplitude signal (la).
^b: The responses of the DARPP-32 state and its output are presented as transient dynamics and long-term state. The transient dynamics is described as trough (∇), essentially flat (↔, and peak (Δ) reflecting the main characteristic of the response. The long-term state of phosphorylation is given in relation to the resting level as decreased (↓), basal (≡), and increased (↑).

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