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Figure 6 | BMC Systems Biology

Figure 6

From: Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro

Figure 6

Alternate mechanism simulations. A, time courses of phospho-MK2 (1st column) or phospho-ATF2 (2nd column) were simulated for the kinetic mechanisms detailed in Figure 5. Time courses were simulated for the single substrate (10 nM or 100 nM ATF2, dashed line) or the dual substrate assay (solid line, 10 nM and 100 nM ATF2). B, the dose-dependence phospho-ATF2 was simulated as a function of MK2 for each kinetic mechanism.

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