Figure 3
From: Confidence from uncertainty - A multi-target drug screening method from robust control theory
Performance envelopes and therapeutic fitting. (A) Temporal simulation of the nonlinear model in Figure 2B with nominal parameters, under healthy conditions (u tot,h = 0.2, and initial conditions given by the healthy steady-state), and diseased conditions (u tot,d = 2, and initial conditions given by the diseased steady-state). Performance envelopes are generated to contain the stochastic envelopes, resulted by the Stochastic Simulation Algorithm (mean ± standard deviation). Nominal results are also shown in dashed lines. (B) Comparison between the performance envelopes and the results obtained from the nonlinear model, starting from the diseased steady-state, with parameter values modified according to the 56 therapies (blue curves).