Number | Parameter description | Parameter | Values | Source |
---|---|---|---|---|
1 | PHD concentration |
| 0.2 | estimate |
2 | Dissociation constant of PHD/HIFα binding |
| 1 | [29] |
3 | (k cat for ODD-hydroxylation)/(basal HIFα degradation rate constant) |
| 500 | [31] |
4 | FIH concentration |
| 1 | estimate |
5 | Dissociation constant of FIH/HIFα binding |
| 1 | set to same as 2 |
6 | (k cat for HIFα CAD-hydroxylation)/(k cat for HIFα ODD-hydroxylation) |
| 1 | estimate |
7 | (KM of FIH for oxygen)/(KM of PHD for oxygen) |
| 0.33 | [30] |
8 | total concentration of FIH target ARs |
| 0 - 500 | varied |
9 | Dissociation constant of FIH/ARD protein binding (unhydroxylated ARs) |
| 1 | set to same as 2 |
10 | (FIH affinity for hydroxylated)/(FIH affinity for unhydroxylated ARs) | γ | 0 - 0.1 | varied |
11 | (basal HIFα degradation rate constant)/(AR degradation rate constant) |
| 1 - 10 | varied |
12 | Dissociation constant of HIF/HRE binding |
| 0.3 | estimate |
13 | Oxygen concentration |
| 0 - 1 | varied |