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Figure 1 | BMC Systems Biology

Figure 1

From: Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model

Figure 1

Bioinformatic analysis of human ankyrin repeats. A. The human ankyrin repeat consensus sequence. Asn-29 in the loop region is the hydroxylation site. The consensus sequence obtained differs at position 1 (N -> D) and position 31 (K -> R) from a previously reported consensus obtained by aligning ARs without restriction to a particular species [41]. Secondary structural elements are indicated. B. Experimentally verified in vivo hydroxylation targets of FIH. Conserved residues are highlighted. The ankyrin consensus as well as the hydroxylation regions of HIF1/2α are given for comparison. C-F. Sequence alignments. Different subgroups of human ankyrin repeats were aligned and displayed as sequence logos [32]. The analysis was restricted to repeats with a length of 32-34 residues (~90% of repeats). Note the much higher degree of conservation in L-8N repeats (C) when compared to non-L-8N repeats (D). Alignments of all human ARs (E), and of verified ankyrin-type in vivo substrates of FIH (F) are given for completion.

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BMC Systems Biology

ISSN: 1752-0509

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