Skip to main content
Figure 5 | BMC Systems Biology

Figure 5

From: Dynamic functional modules in co-expressed protein interaction networks of dilated cardiomyopathy

Figure 5

Analysis of CePPI variations in the identified DCM-related modules. Scatter plots (left) and histograms (right) for PCC values of PPIs in muscle contraction and organ morphogenesis modules in DCM and non-DCM respectively, are shown. In the scatter plot, each dot presents a PPI in the modules; red and green dots represent PPIs with significant correlations (PCC ≥ 0.5 or PCC ≤ -0.5) in DCM and non-DCM samples respectively; green dots with red border represent PPIs with significant correlations in both DCM and non-DCM samples. In the histograms, x-axis represents the categories of PCC and y-axis the frequency (proportion). In addition, green and red lines display the frequencies of PCC for non-DCM and DCM PPIs contained in the modules. (A) Muscle contraction. (B) Organ morphogenesis. Figure 5B suggests that the organ morphogenesis module is more activated in DCM samples, since in the scatter plot, there are more dots of CePPIs for DCM distributed on the significant area than for non-DCM and histogram of DCM also expands to two significant areas than non-DCM. On the other hand, Figure 5A suggests that the muscle contraction module is activated in both non-DCM and DCM samples, because these two distributions for non-DCM and DCM have a high degree of overlap in the histogram. However, the red dots in the scatter plot do not significantly overlap with the green dots, suggesting that these two distributions are produced by different CePPIs.

Back to article page