Figure 4

Effect of increasing ultrasensitivity on mutual fidelity & mutual specificity. MFMS values for networks with CPI, CS, and SC were calculated for 10,000 trials over a large range of parameters (See below for parameter ranges). MFMS values at the 90^th percentile of the distribution were then plotted as a function of degree of various Hill exponents. (A) Dependence of each type of network on n, the degree of ultrasensitivity in the X pathway, where ultrasensitivity in the Y pathway was set to one, m = 1. (B) Dependence on m, the ultrasensitivity of the Y pathway, where n = 1. (Parameter Ranges): $\begin{array}{l}CPI:\left\{\begin{array}{ccccc}1\le a_1/d_1\le 5,& 0.1\le b_1/d_1\le 1,& 0.1\le a_2/d_2^X\le 5,& 0.1\le b_2/d_2^Y\le 5,& .01\le {\epsilon }_Y\le 10\end{array}\right\},\\ CS:\left\{\begin{array}{ccccc}0.1\le a_1/d_1\le 1,& 1\le b_1/d_1\le 5,& 0.1\le a_2/d_2^X\le 5,& 0.1\le b_2/d_2^Y\le 5,& .01\le {\epsilon }_Y\le 10\end{array}\right\},\\ Sc:\left\{\begin{array}{ccccc}1\le a_1/d_1\le 5,& 1\le b_1/d_1\le 5,& 0.1\le a_2/d_2^X\le 5,& 0.1\le b_2/d_2^Y\le 5,& .01\le {\epsilon }_Y\le 10\end{array}\right\}.\end{array}$.