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Table 2 Parameters for Intracellular Gene Network of Epidermal Model

From: Integrative multicellular biological modeling: a case study of 3D epidermal development using GPU algorithms

Parameter

Value

Description

ka

0.0003

Notch (N)/Delta (D) binding rate

kd

0.12

Bound complex (B) unbinding rate

dB

0.19

Bound complex (B) decay rate

aBN

0.01

Bound complex (B) regulation of Notch (N)

bBN

1

Bound complex (B) regulation of Notch (N)

cBN

1

Bound complex (B) regulation of Notch (N)

hBN

-2

Bound complex (B) regulation of Notch (N)

bON

1

Ovol2 (O2) regulation of Notch (N)

cON

0.5

Ovol2 (O2) regulation of Notch (N)

hON

2

Ovol2 (O2) regulation of Notch (N)

dN

0.03

Notch (N) decay rate

aND

0.01

Notch (N) regulation of Delta (D)

bND

1

Notch (N) regulation of Delta (D)

cND

10

Notch (N) regulation of Delta (D)

hND

2

Notch (N) regulation of Delta (D)

dD

0.006

Delta (D) decay rate

aVO

0.1

Ovol1 (O1) regulation of Ovol2 (O2)

bVO

2

Ovol1 (O1) regulation of Ovol2 (O2)

cVO

1

Ovol1 (O1) regulation of Ovol2 (O2)

hVO

2

Ovol1 (O1) regulation of Ovol2 (O2)

bGO

1

TGF-β (G) regulation of Ovol2 (O2)

cGO

1

TGF-β (G) regulation of Ovol2 (O2)

hGO

1

TGF-β (G) regulation of Ovol2 (O2)

dO

1

Ovol2 (O2) decay rate

bOV

2

Ovol2 (O2) regulation of Ovol1 (O1)

cOV

1

Ovol2 (O2) regulation of Ovol1 (O1)

hOV

2

Ovol2 (O2) regulation of Ovol1 (O1)

bAV

1

Basement adhesion (A) regulation of Ovol1 (O1)

cAV

1

Basement adhesion (A) regulation of Ovol1 (O1)

hAV

1

Basement adhesion (A) regulation of Ovol1 (O1)

dV

1

Ovol1 (O1) decay rate

aOM

0.1

Ovol2 (O2) regulation of c-Myc (M)

bOM

1

Ovol2 (O2) regulation of c-Myc (M)

cOM

1

Ovol2 (O2) regulation of c-Myc (M)

hOM

1

Ovol2 (O2) regulation of c-Myc (M)

dM

1

c-Myc (M) decay rate