Table 1 Overall view of tested hepatocyte apoptosis models
Model | Description | Nodes | Edges | Steady States | Feedback Loops | State |
|---|---|---|---|---|---|---|
Model A (All) | All interactions and crosstalk possibilities considered. These include: additional component as a pos. feedback between Akt/PKB and PI3K, additional component as a pos. feedback between Bcl-2/xL and Stat3, additional Akt substrates | 74 | 108 | 4 | 2 positive feedback loops | Apoptosis Survival Apoptosis Survival |
Model 1 | reduced core model (only components listed in official databases) | 66 | 94 | 1 | no feedback loop | Apoptosis |
Model 2 | Core model + ILK pathway and Akt/PKB* | 68 | 100 | 2 | 1 positive feedback loop | Apoptosis Survival |
Model 3 | Core model + TRADD/FADD interactions and ILK pathway | 68 | 100 | 1 | no feedback loop | Apoptosis |
Model 4 | Core model + Akt/PKB* and PI3K pathway | 68 | 100 | 2 | 1 positive feedback loop | Apoptosis Survival |
Model C (Core) | Core model | 67 | 99 | 1 | no feedback loop | Apoptosis |
Model 5 | Model All with a Bid KO | 74 | 107 | 4 | 2 positive feedback loops | Apoptosis Survival Apoptosis Survival |
Model 6 | Model All + cytomegalovirus infection (influence of M45) | 75 | 110 | 4 | 2 positive feedback loops | Apoptosis Survival Apoptosis Survival |
Model 7 | Model All + cytomegalovirus infection (influence of M36) | 75 | 110 | 4 | 2 positive feedback loops | Apoptosis Survival Apoptosis Survival |
Model 8 | Model All + cytomegalovirus infection (influence of M36 and M45) | 76 | 111 | 4 | 2 positive feedback loops | Apoptosis Survival Apoptosis Survival |