Figure 4
Viral infection in hepatocytes. SQUAD simulation data of hepatocytes after TNFα stimulation. M45 interacts with RIP1 and suppresses TNFα-induced NFκB activation. A. SQUAD simulation data of non infected hepatocytes. TNFα (15 min) induced rapid (30 min [17]) NFκB activation. Detailed data from experiment are given in [10]. B. SQUAD simulation data of hepatocytes under influence of viral infection. TNFα mediated IκBα degradation (5 min [18]) was blocked in cells expressing M45. Detailed data from experiment are given in [11]. Activation values for network nodes are calculated and translated into concentration predictions. Maximum value is 1, minimum value is 0. Color code: Concentration curves for RIP1 (cyan), M45 (blue), IκBα (green), NIK (black), NFκB (beige), IKK (red).