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Table 1 Model parameters for cell growth inhibition by 3-NP.

From: A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis

Group

Parameter

Model

Equation

Source of the value

I

w ICL1

Inhibition Model

9

Set to be 0.790 from [44]

 

[SUC]

Inhibition Model

9

Set to be 2.464 mM from [21]

 

K 3-NP, ICL1

Inhibition Model

9

Set to be 0.003 mM from [21, 61]

 

K 3-NP, ICL2

Inhibition Model

9

Set to be 0.110 mM from [21, 61]

 

w MCL 1

Inhibition Model

10

Set to be 0.999 from [44]

II

[C'] (t = 0)

Population Growth Model

14

Obtained by matching experimental cell growth data

 

V m

Population Growth Model

14

 
 

Population Growth Model

14

 
 

K SUC, ICL1

Inhibition Model

9

 

III

K SUC, ICL2

Inhibition Model

9

Assumed (based on [21]) to be 10 × KSUC, ICL1

 

K SUC, MCL 1

Inhibition Model

10

Assumed to be equal to KSUC, ICL1

 

K SUC, MCL 2

Inhibition Model

10

Assumed to be equal to KSUC, ICL2

 

K 3-NP, MCL 1

Inhibition Model

10

Assumed to be equal to K3-NP, ICL1

 

K 3-NP, MCL 2

Inhibition Model

10

Assumed to be equal to K3-NP, ICL2

IV

w ICL2

Inhibition Model

9

Equal to 1-w ICL1

 

w MCL 2

Inhibition Model

10

Equal to 1-w MCL1

  1. The parameter values were grouped into four groups depending on their origin: group I parameters contained those obtained from the literature; group II parameters were obtained by matching experimental growth data; group III parameters were assumed to be related to the parameters of the first two groups; and group IV parameters are, by definition, determined once the group I parameters were defined.