From: A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis
Group | Parameter | Model | Equation | Source of the value |
---|---|---|---|---|
I | w ICL1 | Inhibition Model | 9 | Set to be 0.790 from [44] |
 | [SUC] | Inhibition Model | 9 | Set to be 2.464 mM from [21] |
 | K 3-NP, ICL1 | Inhibition Model | 9 | |
 | K 3-NP, ICL2 | Inhibition Model | 9 | |
 | w MCL 1 | Inhibition Model | 10 | Set to be 0.999 from [44] |
II | [C'] (t = 0) | Population Growth Model | 14 | Obtained by matching experimental cell growth data |
 | V m | Population Growth Model | 14 |  |
 |
| Population Growth Model | 14 | Â |
 | K SUC, ICL1 | Inhibition Model | 9 |  |
III | K SUC, ICL2 | Inhibition Model | 9 | Assumed (based on [21]) to be 10 × KSUC, ICL1 |
 | K SUC, MCL 1 | Inhibition Model | 10 | Assumed to be equal to KSUC, ICL1 |
 | K SUC, MCL 2 | Inhibition Model | 10 | Assumed to be equal to KSUC, ICL2 |
 | K 3-NP, MCL 1 | Inhibition Model | 10 | Assumed to be equal to K3-NP, ICL1 |
 | K 3-NP, MCL 2 | Inhibition Model | 10 | Assumed to be equal to K3-NP, ICL2 |
IV | w ICL2 | Inhibition Model | 9 | Equal to 1-w ICL1 |
 | w MCL 2 | Inhibition Model | 10 | Equal to 1-w MCL1 |