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Figure 6 | BMC Systems Biology

Figure 6

From: A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis

Figure 6

Results for the study of the inhibitory effects of 5'- O -( N -salicylsulfamoyl) adenosine (sAMS). (A) The flux ratio f MS of the mycobactin synthesis reaction as measured in the cell-fee reaction assay as a function of sAMS concentration [sAMS]. The calculated values (solid line) using the inhibition model given in Eq. 15 are in good agreement with the experimentally determined values (squares) [53]. (B) The calculated relative cell concentration R C of Mycobacterium tuberculosis as a function of sAMS inhibitor concentration [sAMS] in iron-deficient and iron-sufficient medium compared to the experimental data [53].

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