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Figure 4 | BMC Systems Biology

Figure 4

From: A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis

Figure 4

The influence of the parameter values on the calculated dose-response curve. Sensitivity analysis of the calculated cell concentration, expressed in units of optical density at 600-nm-wavelength light (OD600), of Mycobacterium tuberculosis after a 16-day growth period as a function of 3-nitropropionate (3-NP) concentration. The analysis was performed for the parameters set to their original values (solid lines), those values increased by 50% (dotted lines). (A-G) Sensitivity of the dose-response curves for variations in the values of the (A) succinate concentration [SUC]; (B) ICL1-catalyzed fraction of the overall inhibitor-free MCL reaction flux w MCL1 ; (C) initial propionate concentration [C'] (t = 0); (D) maximum initial propionate uptake rate V m ; (E) Michaelis-Menten rate constant for the propionate uptake ; (F) Michaelis-Menten rate constant K SUC,MCL1 ; and (G) Michaelis-Menten rate constant K 3-NP,MCL1 .

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