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Figure 6 | BMC Systems Biology

Figure 6

From: Knowledge based identification of essential signaling from genome-scale siRNA experiments

Figure 6

Combined edge hits from PIPA enriched gene sets from HeLa and TOV screens. The three major clusters show enrichment for a variety of biological functions that allow cells to maintain cytoskeletal organization, proteolysis, and prevent apoptosis. The indicated GO Biological Process categories were shown to be significantly enriched after Bonferroni correction. Orange nodes are HeLa hits, yellow nodes are TOV hits, and red nodes are hits in both screens. Edge color indicates the type of protein interaction (red = phosphorylation, green = expression regulation). GO category enrichments were calculated using the Hypergeometric and p-values (< .001) are Bonferroni corrected.

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