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Figure 1 | BMC Systems Biology

Figure 1

From: Knowledge based identification of essential signaling from genome-scale siRNA experiments

Figure 1

"Node hits" represent all single gene siRNA hits while "edge hits" represent siRNA hits connected by a literature-curated protein interactions from Metacore, HPRD, and/or Ingenuity. Higher odds ratios for edge hits (right) show a stronger overlap across replicate HeLa and TOV screens than node hits (left). Odds ratios calculated with universe sizes 18,586 and 11,426 for node hits and edge hits respectively.

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