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Table 3 Predicted genes for Cluster A and B from the extended gene sets.

From: A dynamic network of transcription in LPS-treated human subjects

Cluster

Gene Symbol

Gene Name

A

CFLAR

CASP8 and FADD-like apoptosis regulator

 

CXCL1

chemokine (C-X-C motif) ligand 1

 

EFNA1

ephrin-A1

 

G0S2

G0/G1switch 2

 

IL1R1

interleukin 1 receptor, type I

 

IL1RN

interleukin 1 receptor antagonist

 

OLR1

oxidized low density lipoprotein (lectin-like) receptor 1

 

PLK3

polo-like kinase 3

 

PTX3

pentraxin-related gene, rapidly induced by IL-1 beta

 

RUNX1

runt-related transcription factor 1

 

TNFAIP6

tumor necrosis factor, alpha-induced protein 6

 

TNIP1

TNFAIP3 interacting protein 1

B

CASP4

caspase 4, apoptosis-related cysteine peptidase

 

CD14

CD14 molecule

 

CISH

cytokine inducible SH2-containing protein

 

GBP1

guanylate binding protein 1, interferon-inducible, 67 kDa

 

GBP2

guanylate binding protein 2, interferon-inducible

 

GCH1

GTP cyclohydrolase 1

 

HSPA1A

heat shock 70 kDa protein 1A

 

IFI16

interferon, gamma-inducible protein 16

 

IFIT3

interferon-induced protein with tetratricopeptide repeats 3

 

IFITM1

interferon induced transmembrane protein 1

 

IGF1R

insulin-like growth factor 1 receptor

 

IL10RB

interleukin 10 receptor, beta

 

IRF2

interferon regulatory factor 2

 

ISG15

ISG15 ubiquitin-like modifier

 

ISG20

interferon stimulated exonuclease gene 20 kDa

 

JAK2

Janus kinase 2

 

MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78

 

PLSCR1

phospholipid scramblase 1

 

RIPK1

receptor (TNFRSF)-interacting serine-threonine kinase 1

 

SOCS1

suppressor of cytokine signaling 1

 

STAT2

signal transducer and activator of transcription 2

 

TIMP1

TIMP metallopeptidase inhibitor 1

 

USP18

ubiquitin specific peptidase 18

 

WARS

tryptophanyl-tRNA synthetase

  1. Genes that showed high correlation to the average expression profile of a cluster (c > 0.5) were accepted as part of the cluster.