Figure 5

A dynamic network of transcription. At time zero, LPS is injected, giving rise to transcription factor activation, which then leads to induction or repression of gene expression, production and secretion of cytokines, and initiation of secondary signals. Target genes which correspond to secreted proteins (e.g., IL10, IL1A and IL1B) are noted with green circles, and transcription factors that are regulated by other factors, such as STAT1 and MYC, are noted with cyan circles. The seven major clusters marked in Figure 3A are grouped with orange boxes. Black lines denote activation of a transcription factor by an extracellular signal, red and blue lines show the influence of a transcription factor on a target gene, and green dotted lines indicate secretion of a gene product.