Figure 2

Transcription factor activities calculated using NCA. (A) Predicted activities of the ten transcription factors used in this study. For each transcription factor, rows represent progression in time and columns correspond to the four human subjects. Activities of each row are normalized to the zero time point. (B) Transcription factor activities (blue) compared to gene expression (green), with Pearson correlation coefficients noted. Both activity and expression at each time point are averages normalized to the time = 0 values, and the activity is further scaled for direct comparison with the expression values. (C) Correlation matrix between transcription factor activities. Red represents positive correlation, and blue represents negative correlation. (D) Inferred combinatorial regulation pairs of transcription factors. A blue solid line indicates that the pair was supported by protein-protein interaction knowledge of BIND and high correlation of their activities (>0.75). A black solid line indicates that the pair was only supported by high correlation, and a blue dotted line indicates that the pair was only supported by the interaction database.