Figure 1

Overview of the ECM network in hierarchical order. Regulatory effects via TF s are shown as continuous lines, others as indirect effects as dashed lines. Inhibition is marked by a red T-arrow, induction is illustrated by black arrows. The external signals TGFβ1 and TNFα are shown as light grey circles, the internal SMAD signalling molecules as dark grey squares, TFs are depicted as black (AP-1 components) or white squares, and the target genes are shown as white octagons. This picture was generated using Cytoscape 2.6.0.