Cascading signaling pathways improve the fidelity of a stochastically and deterministically simulated molecular RS latch

Table 1 Constants and values used in stochastic simulations

Constant	Meaning	Value	Units
k _on	Association rate	10⁴	M^-1s^-1
k _off	Dissociation rate	10⁰	s^-1
k _cat	Catalysis rate	10⁴	s^-1
V	Volume of reaction space		m³
m_enzyme	Mass of enzyme	10⁴	gmol^-1
m_substrate	Mass of substrate	10³	gmol^-1
D	Diffusion coefficient	10^-10	m²s^-1

Rate constants were based on kinases and phosphatases from the MAPK pathway, retrieved from the Database of Quantitative Cellular Signalling [33].

ISSN: 1752-0509