Table 2 Top pathways enriched using genetic association research or environmental factor research.
From: Genetic and environmental pathways to complex diseases
Top 15 pathways enriched using phenotype-gene research compiled in the Genetic Association Database | |||
|---|---|---|---|
Pathway Name | KEGG pathway ID | Number of diseases significantly enriched for pathway | Number of environmental factors significantly enriched for pathway |
Antigen processing and presentation | path:hsa04612 | 59 | 57 |
Metabolism of xenobiotics by cytochrome P450 | path:hsa00980 | 49 | 421 |
Hematopoietic cell lineage | path:hsa04640 | 40 | 52 |
Renin-angiotensin system | path:hsa04614 | 28 | 29 |
Retinol metabolism | path:hsa00830 | 27 | 659 |
Natural killer cell mediated cytotoxicity | path:hsa04650 | 26 | 97 |
Neuroactive ligand-receptor interaction | path:hsa04080 | 24 | 30 |
Tyrosine metabolism | path:hsa00350 | 23 | 28 |
Jak-STAT signaling pathway | path:hsa04630 | 20 | 104 |
Complement and coagulation cascades | path:hsa04610 | 16 | 24 |
Linoleic acid metabolism | path:hsa00591 | 15 | 97 |
Cytokine-cytokine receptor interaction | path:hsa04060 | 15 | 63 |
Adipocytokine signaling pathway | path:hsa04920 | 15 | 185 |
T cell receptor signaling pathway | path:hsa04660 | 13 | 38 |
Toll-like receptor signaling pathway | path:hsa04620 | 12 | 114 |
Top 15 pathways enriched using environmental factor-gene research compiled in the Comparative Toxicogenomics Database | |||
Pathway Name | KEGG pathway ID | Number of diseases significantly enriched for pathway | Number of environmental factors significantly enriched for pathway |
Retinol metabolism | path:hsa00830 | 27 | 659 |
Apoptosis | path:hsa04210 | 11 | 457 |
Metabolism of xenobiotics by cytochrome P450 | path:hsa00980 | 49 | 421 |
gamma-Hexachlorocyclohexane degradation | path:hsa00361 | 7 | 224 |
Androgen and estrogen metabolism | path:hsa00150 | 5 | 194 |
PPAR signaling pathway | path:hsa03320 | 11 | 189 |
Adipocytokine signaling pathway | path:hsa04920 | 15 | 185 |
p53 signaling pathway | path:hsa04115 | 7 | 160 |
Toll-like receptor signaling pathway | path:hsa04620 | 12 | 114 |
Focal adhesion | path:hsa04510 | 5 | 114 |
Cell cycle | path:hsa04110 | 2 | 113 |
Pentose and glucuronate interconversions | path:hsa00040 | 2 | 106 |
Jak-STAT signaling pathway | path:hsa04630 | 20 | 104 |
Fc epsilon RI signaling pathway | path:hsa04664 | 6 | 104 |
GnRH signaling pathway | path:hsa04912 | 1 | 100 |