Disruptions of the global pooling structure in G6PD variants. The size of the boxes reflects the size of the redox and phosphate potentials. The NADPH redox state (NADPH/(NADP + NADPH)) is used as the surrogate for the overall redox potential. The A+ and A- variants are almost identical to the normal cell. The chronic hemolytic variants however have significant changes in the size of their redox pools. Additionally, the dynamics of the interactions between the adenosine and pentose phosphate pathways are disrupted in the more severe variants (slanted lines through arrows).