Figure 3
Attenuated and avirulent mutants defective in purine biosynthesis. Attenuated mutants are framed in grey and avirulent mutants are framed in black For unframed genes we could not find information about their corresponding mutant phenotypes in the literature. As shown at the bottom, the host cell is assumed to provide purine nucleosides and bases that can be converted into the required nucleotides via salvage pathways. However, in silico analysis of mutant phenotypes suggests that not all nucleosides (corresponding to the grey boxes: adenosine, deoxyadenosine and guanosine) are provided in sufficient quantities to allow for auxotrophic growth.