IRF-1 functional disease network reconstructed from psoriasis expression profile. The network was generated from psoriasis data as described in the "Results" section. IRF-1(left) was identified as a "divergence" hub functionally linked to multiple downstream target genes differentially expressed in psoriasis. Functional links are highlighted in pink. In MetaCore we have also reconstructed possible physical pathways underlying functional influence (thin lines). The network has 75% of its nodes associated with skin diseases by annotations in MetaCore.