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Figure 4 | BMC Systems Biology

Figure 4

From: Version control of pathway models using XML patches

Figure 4

Simulations of the EGF receptor system. This chart contains simulation traces from various EGF receptor system models. The x-axis represents time in minutes whilst the y-axis represents the concentration of active ERK in molecules/cell. The blue line represents the simulated level of active ERK from the original Brown model, whilst the red line represents simulated active ERK levels with a Rsk knockout, and the green line represents simulated active ERK levels with a P13K knockout. As can be seen, knocking out the PI3K has little effect on active ERK whilst knocking out Rsk has a dramatic effect with the signal switching from a transient to a sustained response.

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