Figure 4

Complexes involved in translation, degradation and post translational modification in yeast. Schematic representation of different multi-protein complexes involved in processes related to translation, which were identified in several triplets of complexes predicted to be coordinately regulated. RNA polymerase I and III complexes are part of the transcriptional machinery that transcribe the ribosome precursors, 35S and 5S, that after proper processing form the ribosome subunits (40S and 60S) [35]. The Processome is involved in ribosome processing and maturation, as is the 20S Proteasome [16]. The eIF2B (eukaryotic initiation factor 2B) complex is required for protein translation initiation and its regulation [36]. Protein translation initiation is the first step in protein synthesis and precedes the elongation and termination steps to complete polypeptide production. Another complex in this pathway is Aut2/Aut7, authophagy related complex which is active in the cytoplasm and responsible for degradation during environmental changes [5, 37]. The M-POL II, mannosyltransferase II is the third complex enzyme in "mannan" modification of N-linked glycan processing in the Golgi apparatus. The two processes of translation and authophagy are both known to be mediated by the TOR complex [4, 5].