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Table 1 Boolean rules for the activation of each component of the network presented in Figure 3.

From: Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance

Target

Logical rules for the activation of target

ERBB1

EGF

ERBB2

EGF

ERBB3

EGF

ERBB1_2

ERBB1 Λ ERBB2

ERBB1_3

ERBB1 Λ ERBB3

ERBB2_3

ERBB2 Λ ERBB3

IGF1R

(ER-α V AKT1) Λ ! ERBB2_3

ER-α

AKT1 V MEK1

c-MYC

AKT1 V MEK1 V ER-α

AKT1

ERBB1 V ERBB1_2 V ERBB1_3 V ERBB2_3 V IGF1R

MEK1

ERBB1 V ERBB1_2 V ERBB1_3 V ERBB2_3 V IGF1R

CDK2

Cyclin E1 Λ ! p21 Λ ! p27

CDK4

Cyclin D1 Λ ! p21 Λ ! p27

CDK6

Cyclin D1

Cyclin D1

AKT1 V MEK1 V ER-α V c-MYC

Cyclin D1*

ER-α Λ c-MYC Λ (AKT1 V MEK1)

Cyclin E1

c-MYC

p21

ER-α Λ ! AKT1 Λ !c-MYC Λ ! CDK4

p27

ER-α Λ ! CDK4 Λ ! CDK2 Λ ! AKT1 Λ !c-MYC

pRB

(CDK4 Λ CDK6)V (CDK4 Λ CDK6 Λ CDK2)

  1. These rules were derived from the references listed in the Additional file 1, Table 1. The refined rules for Cyclin D1 are shown with "*". Symbols "Λ": AND, "V": OR and "!": NOT