Target | Logical rules for the activation of target |
---|---|
ERBB1 | EGF |
ERBB2 | EGF |
ERBB3 | EGF |
ERBB1_2 | ERBB1 Λ ERBB2 |
ERBB1_3 | ERBB1 Λ ERBB3 |
ERBB2_3 | ERBB2 Λ ERBB3 |
IGF1R | (ER-α V AKT1) Λ ! ERBB2_3 |
ER-α | AKT1 V MEK1 |
c-MYC | AKT1 V MEK1 V ER-α |
AKT1 | ERBB1 V ERBB1_2 V ERBB1_3 V ERBB2_3 V IGF1R |
MEK1 | ERBB1 V ERBB1_2 V ERBB1_3 V ERBB2_3 V IGF1R |
CDK2 | Cyclin E1 Λ ! p21 Λ ! p27 |
CDK4 | Cyclin D1 Λ ! p21 Λ ! p27 |
CDK6 | Cyclin D1 |
Cyclin D1 | AKT1 V MEK1 V ER-α V c-MYC |
Cyclin D1* | ER-α Λ c-MYC Λ (AKT1 V MEK1) |
Cyclin E1 | c-MYC |
p21 | ER-α Λ ! AKT1 Λ !c-MYC Λ ! CDK4 |
p27 | ER-α Λ ! CDK4 Λ ! CDK2 Λ ! AKT1 Λ !c-MYC |
pRB | (CDK4 Λ CDK6)V (CDK4 Λ CDK6 Λ CDK2) |