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Table 3 Pearson correlations (r) between the expression profiles of the 20 candidate genes from the IWGCNA and MEblue, CFS severity, and the TPH2 SNP.

From: Integrated Weighted Gene Co-expression Network Analysis with an Application to Chronic Fatigue Syndrome

 

Candidate Genes from IWGCNA: Gene Name and Genbank Accession

Pearson correlations with gene expression profiles

  

MEblue

CFS Severity

TPH2 SNP

  

r: All

Rank*

r: All

p-value

r: M

r: F

r: All

p-value

r: M

r: F

1

FOXN1 (NM_003593)

0.845

195

0.21

0.055

0.27

0.21

0.21

0.018

0.23

0.20

2

PRDX3 (AF118073)

0.848

181

0.26

0.017

0.43

0.21

0.21

0.020

0.32

0.17

3

SUCLA2 (AK001458)

0.844

197

0.20

0.059

0.25

0.18

0.20

0.021

0.36

0.17

4

DCTN2 (NM_006400)

0.909

30

0.18

0.087

0.21

0.16

0.23

0.009

0.41

0.18

5

PGK1 (AB062432)

0.849

176

0.22

0.045

0.37

0.21

0.14

0.108

0.26

0.12

6

SNURF (AF101044)

0.882

77

0.27

0.012

0.51

0.20

0.18

0.037

0.32

0.14

7

PRKCH (BC001000)

0.888

64

0.16

0.143

0.27

0.14

0.15

0.089

0.23

0.13

8

RYK (NM_002958)

0.867

113

0.21

0.048

0.26

0.20

0.12

0.182

0.21

0.09

9

PPP1R14C (AF407165)

0.866

114

0.24

0.025

0.21

0.25

0.21

0.016

0.26

0.19

10

VAMP5 (AF077197)

0.863

124

0.33

0.002

0.47

0.29

0.24

0.007

0.35

0.20

11

PRO0641 (AF090939)

0.853

159

0.32

0.003

0.43

0.30

0.21

0.016

0.25

0.19

12

TMEM50A (AF081282)

0.911

23

0.26

0.014

0.29

0.26

0.17

0.050

0.22

0.16

13

CRNKL1 (AF111802)

0.865

117

0.27

0.012

0.41

0.23

0.22

0.013

0.36

0.18

14

NPAL2 (AK024017)

0.919

10

0.35

0.001

0.37

0.35

0.21

0.020

0.33

0.16

15

TFB2M (AK026314)

0.899

49

0.31

0.004

0.29

0.31

0.21

0.016

0.22

0.19

16

PBLD (AK027673)

0.906

38

0.31

0.003

0.28

0.34

0.17

0.049

0.23

0.15

17

LTV1 (AK027815)

0.856

145

0.30

0.005

0.39

0.29

0.19

0.029

0.29

0.17

18

MED8 (BC010019)

0.869

108

0.29

0.007

0.31

0.28

0.22

0.015

0.35

0.18

19

CD302 (BC020646)

0.817

315

0.24

0.028

0.28

0.25

0.18

0.046

0.29

0.16

20

(XM13557)

0.887

68

0.32

0.002

0.36

0.29

0.19

0.032

0.38

0.15

 

Median:

0.866

114

0.27

0.013

0.30

0.25

0.21

0.021

0.29

0.17

  1. The correlations were computed using all 127 samples studied (All), the 98 female samples and the 29 male samples except for the correlation with severity which only had 87 non-missing scores (64 female and 23 male). The CFS Severity column is bolded for clarity.
  2. *The rank of each gene in terms of its MEblue correlation out of the 8966 genes used to start the analysis.